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In Drosophila , knock-in of a proofreading deficient mtDNA polymerase POLG generates high levels of somatic point mutations and also small indels, but surprisingly limited impact on organismal longevity or fitness. In these flies, the presence of multiple non-synonymous substitutions, even at modest heteroplasmy, disrupts mitochondrial function and dramatically impacts organismal fitness. A detailed analysis of the mutation profile in the POLG and mito-APOBEC1 models reveals that mutation type quality rather than quantity is a critical factor in impacting organismal fitness.
Mitochondria play essential roles in many cellular metabolic and signalling processes, most notably in the production of molecular energy in the form of ATP and in the regulation of cell death.
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T here is still reason to believe the growing coronavirus outbreak in China can be contained, a top World Health Organization official said Saturday, pointing to some evidence that the disease may not be spreading as rapidly as is feared. He also downplayed reports that people infected with the virus may be contagious before they show symptoms — a feature that, if true, would make it much harder to control. The WHO declared the outbreak a global health emergency on Thursday.
Likewise, there has not been a lot of spread from cases discovered in other countries in tourists from China or people returning from China. Still, numbers of cases are growing in big leaps — China reported 2, new cases and 46 additional deaths on Saturday. And those numbers might be higher still but for the fact that China has a backlog of tests to be processed. R0 — pronounced R-naught — is the reproductive number of a disease, the number of people, on average, each infected person goes on to infect.
Most studies so far have estimated the R0 in this outbreak to be between 2 and 2. Ryan would not say what circumstances would lead the WHO to declare this event a pandemic — an outbreak that might be expected to spread around the globe. That kind of discussion, he said, would be a distraction. As of Saturday, he said, the world has seen nearly 12, confirmed cases, all but of them in China.
Nearly two dozen countries outside of China have diagnosed cases.
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